Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CDCA8 |
| Gene Name: | CDCA8 |
| Protein Full Name: | Borealin |
| Alias: | Cell division cycle-associated protein 8;Dasra-B;Pluripotent embryonic stem cell-related gene 3 protein |
| Mass (Da): | 31323 |
| Number AA: | 280 |
| UniProt ID: | Q53HL2 |
| Locus ID: | 55143 |
| COSMIC ID: | CDCA8 |
| Gene location on chromosome: | 1p34.3 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.21 |
| Commentary on involvement of protein in cancer: | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. |