Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MIA3 |
| Gene Name: | MIA3 |
| Protein Full Name: | Melanoma inhibitory activity protein 3 |
| Alias: | ARNT; C219 reactive peptide; C219-reactive peptide; D320; FLJ39207; KIAA0268; Melanoma inhibitory activity family, member 3; TANGO; Transport and Golgi organization protein 1; UNQ6077 |
| Mass (Da): | 213702 |
| Number AA: | 1907 |
| UniProt ID: | Q5JRA6 |
| Locus ID: | 375056 |
| COSMIC ID: | MIA3 |
| Gene location on chromosome: | 1q41 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 19629 |
| Percent of cancer specimens with mutations: | 1.23 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | MIA3 is a transmembrane protein on the ER that is required specifically for collagen VII secretion. It does not appear to play a role in global protein secretion. Although its function in cancer is unknown, induced MIA3 expression resulted in significantly decreased cell motility and invasive potential while knockdown of MIA3 promoted cell invasion and migration in vitro. |