Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARHGAP21 |
| Gene Name: | ARHGAP21 |
| Protein Full Name: | Rho GTPase-activating protein 21 |
| Alias: | ARHGAP10; KIAA1424; RHG21; Rho GTPase activating protein 21; Rho GTPase-activating protein 10; Rho-GTPase activating protein 10; Rho-type GTPase-activating protein 21 |
| Mass (Da): | 217331 |
| Number AA: | 1957 |
| UniProt ID: | Q5T5U3 |
| Locus ID: | 57584 |
| COSMIC ID: | ARHGAP21 |
| Gene location on chromosome: | 10p12.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 1.34 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ARHGAP21 functions as a GTPase-activating protein for RhoA and Cdc42 thus decreasing their activity. It also functions to recruit CTNNA1 to adherens junction. Loss of ARHGAP21 has been associated with cell spreading and accumulation of F-actin stress fibres. |