Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAGI3 |
| Gene Name: | MAGI3 |
| Protein Full Name: | Membrane-associated guanylate kinase inverted 3 |
| Alias: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 |
| Mass (Da): | 162948 |
| Number AA: | 0 |
| UniProt ID: | Q5TCQ9 |
| Locus ID: | 260425 |
| COSMIC ID: | MAGI3 |
| Gene location on chromosome: | 1p13.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signalling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signalling cascade via its interaction with FZD4 and VANGL2. Prodominant effect is inhibitory on these systems and therefore loss of function may promote oncogenesis |