Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZNF318 |
| Gene Name: | ZNF318 |
| Protein Full Name: | Zinc finger protein 318 |
| Alias: | HRIHFB2436 |
| Mass (Da): | 251112 |
| Number AA: | 2279 |
| UniProt ID: | Q5VUA4 |
| Locus ID: | 7705 |
| COSMIC ID: | ZNF318 |
| Gene location on chromosome: | 6pter-p12.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 1.42 |
| Normal role description: | ZNF318 is a zinc-finger domain containing protein which binds DNA. This protein has been found to interact with the nuclear androgen receptor and act as repressor of its activity. Mutations of ZNF318 have been detected in breast cancers, however their functional effect is not well characterized. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org. Less than 3% mutation in CNS. |