Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DAB2IP |
| Gene Name: | DAB2IP |
| Protein Full Name: | Disabled homolog 2-interacting protein |
| Alias: | AF9Q34; AIP1; ASK1-interacting protein 1; ASK-interacting; ASK-interacting 1; ASK-interacting protein; DAB2 interacting; DAB2 interacting protein; DAB2 interaction; DAB2-disabled 2-interacting; DAB2P; DIP1/2; DOC-2/DAB2 interactive protein; KIAA1743; NGAP-like; NGAP-like protein |
| Mass (Da): | 131625 |
| Number AA: | 1189 |
| UniProt ID: | Q5VWQ8 |
| Locus ID: | 153090 |
| COSMIC ID: | DAB2IP |
| Gene location on chromosome: | 9q34 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.87 |
| Normal role description: | DAB2IP is a RasGAP protein. It inactivates Ras by inducing the catalysis of GTP to GDP. It is also found to activate TNF/TRAF2-induced MAP3K5-JNK resulting in apoptosis. Expression is decreased in cancer leading to dysregulation of Ras pathway. |