Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FBXO31 |
| Gene Name: | FBXO31 |
| Protein Full Name: | F-box only protein 31 |
| Alias: | F-box protein 31; FBX14; FBX31; FBXO14; MGC15419 |
| Mass (Da): | 60645 |
| Number AA: | 539 |
| UniProt ID: | Q5XUX0 |
| Locus ID: | 79791 |
| COSMIC ID: | FBXO31 |
| Gene location on chromosome: | 16q24.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | Halts cell cycle progression following DNA damage in G1 arrest. Recognizes phosphorylated cyclin-D1 and targets it for degredation. Contains an Fbox motif. LOH implicated in cancer by permitting aberrant cellular divison. |