Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP1S |
| Gene Name: | MAP1S |
| Protein Full Name: | Microtubule-associated protein 1S |
| Alias: | BPY2-interacting protein 1; BPY2IP1; C19orf5; DKFZp761H0722; FLJ10669; MAP 1S; MAP8; Microtubule-associated protein 8; Variable charge Y chromosome 2-interacting protein 1; VCY2-interacting protein 1; VCY2IP1; VCY2IP-1 |
| Mass (Da): | 112211 |
| Number AA: | 1059 |
| UniProt ID: | Q66K74 |
| Locus ID: | 55201 |
| COSMIC ID: | MAP1S |
| Gene location on chromosome: | 19p13.11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.77 |
| Normal role description: | MAPS1 is a microtuble-associated protein that mediates mitochondrial aggregation resulting cell death. Association with cancer is unclear. |
| Commentary on involvement of protein in cancer: | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule-organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles |