Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MUC17 |
| Gene Name: | MUC17 |
| Protein Full Name: | Mucin-17 |
| Alias: | Small intestinal mucin-3 |
| Mass (Da): | 451741 |
| Number AA: | 4493 |
| UniProt ID: | Q685J3 |
| Locus ID: | 140453 |
| COSMIC ID: | MUC17 |
| Gene location on chromosome: | 7q22.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19609 |
| Percent of cancer specimens with mutations: | 5.05 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Wide range of points mutations, without complex mutations, insertions or deletions, across the full length of the protein. |
| Normal role description: | MUC17 is a membrane glycoprotein with highly conserved homology through species. It is expressed on intestinal mucosal surfaces and upregulated in response to NF-kB signalling. Similarly, MUC17 is aberrantly expressed in pancreatic adenocarcinomas as compared to no expression in the normal pancreas or benign pancreatitis. Mechanism of oncogenesis unclear - may reflect loss of differentiation or phenotypic transformation of certain tumour cells. |