Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ACSM2B |
| Gene Name: | ACSM2B |
| Protein Full Name: | Acyl-coenzyme A synthetase ACSM2B, mitochondrial |
| Alias: | A-923A4.1; ACS2B; ACSM2; Acyl-coenzyme A synthetase ACSM2B, mitochondrial; Butyrate--CoA ligase 2B; Butyryl coenzyme A synthetase 2B; EC 6.2.1.2; Medium chain acyl-CoA synthetase; MGC150530; Middle-chain acyl-CoA synthetase 2B; Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A |
| Mass (Da): | 64257 |
| Number AA: | 577 |
| UniProt ID: | Q68CK6 |
| Locus ID: | 348158 |
| COSMIC ID: | ACSM2B |
| Gene location on chromosome: | 16p12.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 1.03 |
| Normal role description: | Carbohydrate Metabolism - butanoate. |
| Commentary on involvement of protein in cancer: | Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro). Activated by monovalent cations, such as potassium, rubidium or ammonium. |