Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PLAG1 |
| Gene Name: | PLAG1 |
| Protein Full Name: | Zinc finger protein PLAG1 |
| Alias: | Pleiomorphic adenoma gene 1 protein |
| Mass (Da): | 55909 |
| Number AA: | 500 |
| UniProt ID: | Q6DJT9 |
| Locus ID: | 5324 |
| COSMIC ID: | PLAG1 |
| Gene location on chromosome: | 8q12 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20443 |
| Percent of cancer specimens with mutations: | 0.54 |
| Deregulated in translocations: | CTNNB1; LIFR; HAS2 |
| Normal role description: | PLAG1 is a transcriptional regulator. It is involved in positive regulation of IGF2, CRLF1, CRABP2, CRIP2, and PIGF. Increase in IGF2 can lead to cell growth and proliferation. In cancer, gene rearrangements with itself or regulatory elements from other genes causes dysregulation of expression and oncogenesis. |