Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SFRP4 |
| Gene Name: | SFRP4 |
| Protein Full Name: | Secreted frizzled-related protein 4 |
| Alias: | frizzled protein, human endometrium; FRP-4; FRPHE |
| Mass (Da): | 39827 |
| Number AA: | 346 |
| UniProt ID: | Q6FHJ7 |
| Locus ID: | 6424 |
| COSMIC ID: | SFRP4 |
| Gene location on chromosome: | 7p14.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20151 |
| Percent of cancer specimens with mutations: | 0.66 |
| Gene undergoes hypermethylation: | Malignant Pleural Mesothelioma; Pancreatic Cancer; Gastric Carcinoma; Esophageal Adenocarcinoma |
| Normal role description: | Modulator of Wnt pathway. Expression is regulated by estrogen and progesterone and increases apoptosis during ovulation. Downregulated expression is associated with human cancers as well as overexpression. |