Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RALGAPA1 |
| Gene Name: | RALGAPA1 |
| Protein Full Name: | Ral GTPase-activating protein subunit alpha-1 |
| Alias: | GAP-related-interacting partner to E12; GRIPE; Tuberin-like protein 1 |
| Mass (Da): | 229832 |
| Number AA: | 2036 |
| UniProt ID: | Q6GYQ0 |
| Locus ID: | 253959 |
| COSMIC ID: | RALGAPA1 |
| Gene location on chromosome: | 14q13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19673 |
| Percent of cancer specimens with mutations: | 1.21 |
| Normal role description: | RALGAPA1 is the catalytic α subunit of the heterodimeric RalGAP1 complex together with RALGAPB, which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. It is mainly located in the cytoplasm but is translocated to the nucleus when it associates with TCF3/E12. Its exact role in oncogenesis is unclear. |
| Commentary on involvement of protein in cancer: | 1/1 laryngeal tumour samples was also mutated (mis-sense) |