Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLHL10 |
| Gene Name: | KLHL10 |
| Protein Full Name: | Kelch-like protein 10 |
| Mass (Da): | 68942 |
| Number AA: | 608 |
| UniProt ID: | Q6JEL2 |
| Locus ID: | 317719 |
| COSMIC ID: | KLHL10 |
| Gene location on chromosome: | 17q21.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19764 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | KLHL10 is a subunit of E3 ubiquitin ligase complex. It is responsible for caspase activation and degradation of inhibitors of apoptosis BRUCE to stimulate apoptosis. Reduced expression can increase resistance to apoptosis and provide growth advantage for cancer cells. |