Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TET2 |
| Gene Name: | TET2 |
| Protein Full Name: | Methylcytosine dioxygenase TET2 |
| Alias: | FLJ20032; KIAA1546; LOC54790; Probable methylcytosine dioxygenase TET2: Probable methylcytosine dioxygenase TET2: Probable methylcytosine dioxygenase TET2: TET2 protein; Tet oncogene family member 2 |
| Mass (Da): | 223811 |
| Number AA: | 2002 |
| UniProt ID: | Q6N021 |
| Locus ID: | 54790 |
| COSMIC ID: | TET2 |
| Gene location on chromosome: | 4q24 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 29707 |
| Percent of cancer specimens with mutations: | 6.89 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with point mutations, complex mutations, insertions and deletions over entire protein length. |
| Normal role description: | TET2 is a methylcytosine dioxygenase. It catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and plays an important role in myelopoiesis. Mutations in this gene have been observed in haematopoietic and lymphoid tumors. |