Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAST2 |
| Gene Name: | MAST2 |
| Protein Full Name: | Microtubule-associated serine/threonine-protein ki |
| Alias: | EC 2.7.11.1; KIAA0807; MAST205; Microtubule associated serine/threonine kinase 2 |
| Mass (Da): | 196436 |
| Number AA: | 1798 |
| UniProt ID: | Q6P0Q8 |
| Locus ID: | 23139 |
| COSMIC ID: | MAST2 |
| Gene location on chromosome: | 1p34.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19596 |
| Percent of cancer specimens with mutations: | 1.12 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | MAST2 is a protein serine/threonine kinase that can regulate LPS-induced IL-12 synthesis in macrophages by inhibiting TRAF6 and TRAF6-dependent NF-kB activation. Its role in cancer is unknown, but K275E and G655A mutations have been associated with ovarian mucinous carcinoma and breast mucinous carcinoma samples, respectively. |
| Commentary on involvement of protein in cancer: | no entry in AGO |