Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BRWD3 |
| Gene Name: | BRWD3 |
| Protein Full Name: | Bromodomain and WD repeat-containing protein 3 |
| Alias: | BRODL; bromodomain and WD repeat domain containing 3; FLJ38568 |
| Mass (Da): | 203626 |
| Number AA: | 1802 |
| UniProt ID: | Q6RI45 |
| Locus ID: | 254065 |
| COSMIC ID: | BRWD3 |
| Gene location on chromosome: | Xq21.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 1.65 |
| Deregulated in translocations: | t(X;11)(q21;q23) |
| Normal role description: | Downstream protein in the Jak/Stat signalling cascade in hematopoeic cells and is involved in hematopoiesis. Although BRWD3 levels are lower in certain blood cancers suggesting possible role as a tumour suppressor, mutations of the protein have also been shown to suppress malignant hematologic cells. |