Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Shc4 |
| Gene Name: | SHC4 |
| Protein Full Name: | SHC-transforming protein 4 |
| Alias: | rai-like protein; RaLP; SHC (Src homology 2 domain containing) family, member 4; SHC (Srcy 2 domain containing) family, member 4 |
| Mass (Da): | 68785 |
| Number AA: | 630 |
| UniProt ID: | Q6S5L8 |
| Locus ID: | 399694 |
| COSMIC ID: | SHC4 |
| Gene location on chromosome: | 15q21.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.58 |
| Normal role description: | SHC4 is participates in many signalling pathways. It interacts with Ras and MAPK pathways to induce migration and invasive phenotype in cancer, particularly melanoma. |