Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | OLFM4 |
| Gene Name: | OLFM4 |
| Protein Full Name: | Olfactomedin-4 |
| Alias: | Antiapoptotic protein GW112;G-CSF-stimulated clone 1 protein;hOLfD |
| Mass (Da): | 57280 |
| Number AA: | 510 |
| UniProt ID: | Q6UX06 |
| Locus ID: | 10562 |
| COSMIC ID: | OLFM4 |
| Gene location on chromosome: | 13q14.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19605 |
| Percent of cancer specimens with mutations: | 0.72 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | OFLM4 is a secreted protein that may promote the proliferation of pancreatic cancer cells by favouring the S/G2 transition. In myeloid leukemic cell lines, however, it can inhibit cell growth and induce cell differentiation and apoptosis. It can also facilitate cell adhesion especially through cell surface lectins and cadherins. |