Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ATF7IP |
| Gene Name: | ATF7IP |
| Protein Full Name: | Activating transcription factor 7-interacting prot |
| Alias: | Activating transcription factor 7 interacting protein; ATFa-associated modulator; FLJ10139; FLJ10688; MCAF; MCAF1; P621 |
| Mass (Da): | 136422 |
| Number AA: | 1270 |
| UniProt ID: | Q6VMQ6 |
| Locus ID: | 55729 |
| COSMIC ID: | ATF7IP |
| Gene location on chromosome: | 12p13.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19742 |
| Percent of cancer specimens with mutations: | 1.11 |
| Normal role description: | ATF7IP is a nuclear localized protein involved in transcriptional regulation. It will associate with heterochromatin and has a dual role in activating or repressing transcription depending on associated factors. ATF7IP plays a role in maintaining heterochromatin formation and its dysregulation may lead to overexpression of oncogenic genes in cancer. |