Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BCoR |
| Gene Name: | BCOR |
| Protein Full Name: | BCL-6 corepressor |
| Alias: | Bcl6 corepressor; KIAA1575 |
| Mass (Da): | 192189 |
| Number AA: | 1755 |
| UniProt ID: | Q6W2J9 |
| Locus ID: | 54880 |
| COSMIC ID: | BCOR |
| Gene location on chromosome: | Xp11.4 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 21609 |
| Percent of cancer specimens with mutations: | 2 |
| Commonly recorded point mutations: | N1425S (17) |
| Normal role description: | BCOR is a transcriptional corepressor. which may act to inhibit gene expression through recruitment of histone deactylases including HDAC1, HDAC3 and HDAC5. BCOR may be involved in suppressing tumour growth by inhibiting gene expression. |