Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RASSF6 |
| Gene Name: | RASSF6 |
| Protein Full Name: | Ras association domain-containing protein 6 |
| Alias: | RASF6 |
| Mass (Da): | 43384 |
| Number AA: | 369 |
| UniProt ID: | Q6ZTQ3 |
| Locus ID: | 166824 |
| COSMIC ID: | RASSF6 |
| Gene location on chromosome: | 4q13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19808 |
| Percent of cancer specimens with mutations: | 0.4 |
| Gene undergoes hypermethylation: | childhood leukaemias; in 94% (48/51)of B-ALL and 41% (12/29) of T-ALL |
| Normal role description: | Involved in apoptosis via caspase-dependent and caspase-independent ways. Effector of K-Ras mediated apoptosis. Negatively regulates proapoptotic MST2. Interacts with MOAP-1 in the MOAP apoptotic pathway. Downregulation associated with many human cancers. |
| Commentary on involvement of protein in cancer: | No mutations have been reported on the Atlas of Oncology. |