Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PHLPP2 |
| Gene Name: | PHLPP2 |
| Protein Full Name: | PH domain leucine-rich repeat-containing protein p |
| Alias: | PH domain leucine-rich repeat-containing protein phosphatase-like |
| Mass (Da): | 146751 |
| Number AA: | 1323 |
| UniProt ID: | Q6ZVD8 |
| Locus ID: | 23035 |
| COSMIC ID: | PHLPP2 |
| Gene location on chromosome: | 16q22.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19801 |
| Percent of cancer specimens with mutations: | 0.9 |
| Normal role description: | PHLPP2 is a protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1 -- a kinases, that when dephosphorylated, acts in a pro-apoptotic manner and decreases cell proliferation. Downregulation in PHLPP2 has been found in various neoplasms, including: breast, ovarian, prostate, kidney, and colon cancer, as well as chronic myloid leukemia. |