Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | XIRP1 |
| Gene Name: | XIRP1 |
| Protein Full Name: | Xin actin-binding repeat-containing protein 1 |
| Alias: | Cardiomyopathy associated protein 1; Cardiomyopathy-associated protein 1; DKFZp451D042; Xin; Xin A; Xin actin-binding repeat containing 1; XIRP1 |
| Mass (Da): | 198561 |
| Number AA: | 1843 |
| UniProt ID: | Q702N8 |
| Locus ID: | 165904 |
| COSMIC ID: | XIRP1 |
| Gene location on chromosome: | 3p22.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19690 |
| Percent of cancer specimens with mutations: | 1.57 |
| Normal role description: | XIRP1 colocalizes with actin stress fibres and protects the actin filaments from depolymerization. |
| Commentary on involvement of protein in cancer: | 1/44 CNS samples was also mutated (Sanger COSMIC) |