Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARMCX2 |
| Gene Name: | ARMCX2 |
| Protein Full Name: | Armadillo repeat-containing X-linked protein 2 |
| Alias: | ARM protein lost in epithelial cancers on chromosome X 2 |
| Mass (Da): | 65683 |
| Number AA: | 632 |
| UniProt ID: | Q7L311 |
| Locus ID: | 9823 |
| COSMIC ID: | ARMCX2 |
| Gene location on chromosome: | Xq21.33-q22.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.69 |
| Normal role description: | ARMCX2 contains a transmembrane domain at the N-termina and a single Armadillo (arm) repeat, which is involved in development, maintenance of tissue integrity, and tumorigenesis. Its expression is lost or significantly reduced in carcinomas, indicating that it functions as a tumour suppressor in normal tissue. |