Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KDM3B |
| Gene Name: | KDM3B |
| Protein Full Name: | Lysine-specific demethylase 3B |
| Alias: | C5orf7; JHD2B; Jumonji domain-containing protein 1B; KIAA1082; Lysine (K)-specific demethylase 3B; NET22; Nuclear protein 5qNCA |
| Mass (Da): | 191611 |
| Number AA: | 1761 |
| UniProt ID: | Q7LBC6 |
| Locus ID: | 51780 |
| COSMIC ID: | KDM3B |
| Gene location on chromosome: | 5q31.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20115 |
| Percent of cancer specimens with mutations: | 1.35 |
| Normal role description: | KDM3B is a demethylase. It is reponsible for demethylation of H3 lys-9. In cancer it is often lost thus preventing reactivation of silenced genes. |