Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RNF144B |
| Gene Name: | RNF144B |
| Protein Full Name: | E3 ubiquitin-protein ligase RNF144B |
| Alias: | IBR domain-containing protein 2;RING finger protein 144B;p53-inducible RING finger protein |
| Mass (Da): | 33697 |
| Number AA: | 303 |
| UniProt ID: | Q7Z419 |
| Locus ID: | 255488 |
| COSMIC ID: | RNF144B |
| Gene location on chromosome: | 6p22.3 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.17 |
| Commentary on involvement of protein in cancer: | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. |