Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRPM1 |
| Gene Name: | TRPM1 |
| Protein Full Name: | Transient receptor potential cation channel subfam |
| Alias: | LTRPC1; melastatin 1; MLSN1; transient receptor potential cation channel, subfamily M, member 1 |
| Mass (Da): | 182178 |
| Number AA: | 1603 |
| UniProt ID: | Q7Z4N2 |
| Locus ID: | 4308 |
| COSMIC ID: | TRPM1 |
| Gene location on chromosome: | 15q13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19629 |
| Percent of cancer specimens with mutations: | 1.47 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with several point mutations, but no complex, insertion or deletion mutants. |
| Normal role description: | Acts as a calcium channel, essential for the depolarizing photoresponse of retinal ON bipolar cells. May be important for calcium uptake in melanocytes. Part of GRM6 signalling cascade. Suggested to be involved in metastasis suppression. Downregulation in melanoma associated with poor prognosis. |