Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Net1 |
| Gene Name: | NET1 |
| Protein Full Name: | Neuroepithelial cell-transforming gene 1 protein |
| Alias: | ARHG8; ARHGEF8; NET1A; neuroepithelial cell transforming 1; Neuroepithelial cell transforming gene 1 protein; p65 Net1 proto- oncogene; Rho guanine nucleotide exchange factor 8 |
| Mass (Da): | 67740 |
| Number AA: | 596 |
| UniProt ID: | Q7Z628 |
| Locus ID: | 10276 |
| COSMIC ID: | NET1 |
| Gene location on chromosome: | 10p15.1 |
| Cancer protein type: | BOTH |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19781 |
| Percent of cancer specimens with mutations: | 0.36 |
| Normal role description: | NET1 is a guanine nucleotide exchange factor for RhoA GTPase. In cancer, upregulatin induces RhoA activities including cytoskeletal rearrangements and cell migration thus promoting invasive behavior of gastric cancer. May also be involved in activation of JNK pathway to induce RhoB-mediated cell death during stress in breast cancer. |