Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: RbBP6
Gene Name: RBBP6
Protein Full Name: E3 ubiquitin-protein ligase RBBP6
Alias: My038; P2PR; P53-associated cellular protein of testis; PACT; RBQ1
Mass (Da): 201564
Number AA: 1792
UniProt ID: Q7Z6E9
Locus ID: 5930
COSMIC ID: RBBP6
Gene location on chromosome: 16p12.1
Cancer protein type: OP
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: PROMOTES
Number of cancer specimens: 19717
Percent of cancer specimens with mutations: 1.4
Mutations observed as inherited: NA
Found in amplified chromosomal regions in human cancers: NA
Deregulated in translocations: NA
Deregulated by viral insertion: NA
Transduced into viral genome: NA
Gene undergoes hypermethylation: NA
Normal role description: RBBP6 is a E3 ubiquitin-protein ligase that ubiquitinates YBX1, a putative anti-metastatic protein, and targets it for degradation by the proteasome. It may also be a negative regulator of p53/TP53 by acting as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, which would increase MDM2-mediated ubiquination and degradation of p53. This would promote cell proliferation and tumour growth.


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