Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AMIGO2 |
| Gene Name: | AMIGO2 |
| Protein Full Name: | Amphoterin-induced protein 2 |
| Alias: | adhesion molecule with ig-like domain 2; ali1; alivin 1; amgo2; amigo2; amigo2 protein; amphoterin-induced gene and open reading frame 2; dega; dega/amigo-2; transmembrane protein amigo2 |
| Mass (Da): | 57934 |
| Number AA: | 522 |
| UniProt ID: | Q86SJ2 |
| Locus ID: | 347902 |
| COSMIC ID: | AMIGO2 |
| Gene location on chromosome: | 12q13.11 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.49 |
| Normal role description: | AMIGO2 is a cell adhesion molecule related to AMIGO. It contains a leucine rich domain and is localized at the cell surface suggesting it plays a role in cell adhesion and signal transduction. In neurons it has been shown to inhibit apoptosis under some conditions.. It is often found to be overexpressed in some cancers which can lead to signal dysregulation and tumorigenesis. |