Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZBTB33 |
| Gene Name: | ZBTB33 |
| Protein Full Name: | Transcriptional regulator Kaiso |
| Alias: | Zinc finger and BTB domain-containing protein 33 |
| Mass (Da): | 74484 |
| Number AA: | 672 |
| UniProt ID: | Q86T24 |
| Locus ID: | 10009 |
| COSMIC ID: | ZBTB33 |
| Gene location on chromosome: | Xq24 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.64 |
| Normal role description: | Via its zinc finger domain, Kaiso binds DNA and functions as both a repressor and activator of transcription. Kaiso recognizes methylated CpG dinucleotides as well as a sequence-specific site (TCCTGCNA). As such, ultimate role in oncogenesis will depend on which genes are upregulated or suppressed. However, empirically, Kaiso has been demonstrated to block transcription of TSP and upregulation of Kaiso appears to promote oncogenesis. |