Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PEG10 |
| Gene Name: | PEG10 |
| Protein Full Name: | Paternally expressed gene 10 protein |
| Alias: | PEG10 protein |
| Mass (Da): | 80155 |
| Number AA: | 708 |
| UniProt ID: | Q86TG7 |
| Locus ID: | 23089 |
| COSMIC ID: | PEG10 |
| Gene location on chromosome: | 7q21.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19559 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | PEG10 Is implicated in cell proliferation and inhibition of apoptosis in liver regeneration, hepatocellular carcinoma and B cell acute and chronic lymphocytic leukemia. It also has a role in development of placenta shown in mice. In cancer it is over expressed providing a growth and survival advantage. |