Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRUNE |
| Gene Name: | PRUNE |
| Protein Full Name: | Protein prune homolog |
| Alias: | DRES-17; EC 3.6.1.1; HTCD37; TcD37 |
| Mass (Da): | 50228 |
| Number AA: | 453 |
| UniProt ID: | Q86TP1 |
| Locus ID: | 58497 |
| COSMIC ID: | PRUNE |
| Gene location on chromosome: | 1q21 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.3 |
| Commentary on involvement of protein in cancer: | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. |