Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LDB1 |
| Gene Name: | LDB1 |
| Protein Full Name: | LIM domain-binding protein 1 |
| Alias: | Carboxyl-terminal LIM domain-binding 2; CLIM2; CLIM-2; LIM domain binding 1 |
| Mass (Da): | 46533 |
| Number AA: | 411 |
| UniProt ID: | Q86U70 |
| Locus ID: | 8861 |
| COSMIC ID: | LDB1 |
| Gene location on chromosome: | 10q24 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 19780 |
| Percent of cancer specimens with mutations: | 0.34 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | LDB1 regulates the transcription activity of various transcription factors containing the LIM domain by acting as an adaptor protein. Together with LMO, it is involved in the regulation of erythrocyte development and maintains erythroid precursors in an immature state. LDB1 is often found to be overexpressed in invasive oral squamous cell carcinoma. A R299Q mutation was associated with a colorectal cancer sample. |