Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAGI2 |
| Gene Name: | MAGI2 |
| Protein Full Name: | Membrane-associated guanylate kinase, WW and PDZ d |
| Alias: | ACVRIP1; ARIP1; Atrophin-1 interacting protein 1; Atrophin-1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; KIAA0705; MAGI-2; Membrane associated guanylate kinase inverted-2; Membrane associated guanylate kinase, WW and PDZ domain containing 2; Membrane-associated guanylate kinase inverted 2 |
| Mass (Da): | 158754 |
| Number AA: | 1455 |
| UniProt ID: | Q86UL8 |
| Locus ID: | 9863 |
| COSMIC ID: | MAGI2 |
| Gene location on chromosome: | 7q21 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19994 |
| Percent of cancer specimens with mutations: | 2.03 |
| Normal role description: | MAGI2 is a scaffold molecule at synaptic junctions. It assembs neurotransmitter receptors and cell adhesion proteins.It may also play a role in regulating activin-mediated signalling in neuronal cells. Since MAGI2 enhances PTEN's suppression of AKT1 -- a oncoprotein -- it could serve as a tumour suppressor. Mutations in this gene have been found in colon and ovarian tumors. |
| Commentary on involvement of protein in cancer: | Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. |