Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ITIH5 |
| Gene Name: | ITIH5 |
| Protein Full Name: | Inter-alpha-trypsin inhibitor heavy chain H5 |
| Mass (Da): | 104576 |
| Number AA: | 942 |
| UniProt ID: | Q86UX2 |
| Locus ID: | 8076 |
| COSMIC ID: | ITIH5 |
| Gene location on chromosome: | 10p14 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 1.15 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with some point mutations , but no complex mutations, insertions or deletions. |
| Normal role description: | ITIH5 is a heavy chain component of the inter-alpha-trypsin inhibitor (ITI) family. It is involved in stablizing the extracellular matrix and inhibiting metastisis. Mutations in this gene are implicated in ovarian and brain cancer. |
| Commentary on involvement of protein in cancer: | May act as a tumor suppressor. |