Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | P2RY8 |
| Gene Name: | P2RY8 |
| Protein Full Name: | P2Y purinoceptor 8 |
| Alias: | G-protein coupled purinergic receptor P2Y8; P2Y8; purinergic receptor P2Y, G-protein coupled, 8 |
| Mass (Da): | 40635 |
| Number AA: | 359 |
| UniProt ID: | Q86VZ1 |
| Locus ID: | 286530 |
| COSMIC ID: | P2RY8 |
| Gene location on chromosome: | Xp22.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20377 |
| Percent of cancer specimens with mutations: | 0.58 |
| Deregulated in translocations: | P2RY8/CRLF2 FUSION GENE. Mullighan et al. (2009) reported a recurring interstitial deletion of pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL (613035) that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2 |
| Normal role description: | Probable receptor for purines coupled to G proteins. Fusion protein P2RY8/CRLF2 requires JAK mutations to facilitate oncogenesis. Role as an independent oncogene not established. |