Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | JAZF1 |
| Gene Name: | JAZF1 |
| Protein Full Name: | Juxtaposed with another zinc finger protein 1 |
| Alias: | DKFZp761K2222; JAZF zinc finger 1; Juxtaposed with another zinc finger 1; Juxtaposed with another zinc finger gene 1; Juxtaposed with another zinc finger protein 1: TAK1-interacting protein 27: Zinc finger protein 802: Juxtaposed with another zinc finger protein 1: TAK1-interacting protein 27: Zinc finger protein 802; TAK1-interacting 27; TAK1-interacting protein 27; TIP27; Zinc finger protein 802; ZNF802 |
| Mass (Da): | 27079 |
| Number AA: | 243 |
| UniProt ID: | Q86VZ6 |
| Locus ID: | 221895 |
| COSMIC ID: | JAZF1 |
| Gene location on chromosome: | 7p15.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20433 |
| Percent of cancer specimens with mutations: | 0.16 |
| Deregulated in translocations: | SUZ12; JJAZ1; PHF1 |
| Normal role description: | JAZF1 is a regulator of transcription. It is a transcriptional repressor of TAK1. Chromosome translocation events lead to fusion genes that promote oncogenesis. |