Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NLRP8 |
| Gene Name: | NLRP8 |
| Protein Full Name: | NACHT, LRR and PYD domains-containing protein 8 |
| Alias: | CLR19.2; NACHT, LRR and PYD containing 8; NALP8; NLR family, pyrin domain containing 8; NOD16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8; PAN4 |
| Mass (Da): | 119430 |
| Number AA: | 1048 |
| UniProt ID: | Q86W28 |
| Locus ID: | 126205 |
| COSMIC ID: | NLRP8 |
| Gene location on chromosome: | 19q13.43 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19935 |
| Percent of cancer specimens with mutations: | 0.16 |
| Normal role description: | NALP8 is involved in the activation of proinflammatory caspases via its involvement in the multiprotein complex the inflammasome. It contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminal leucine-rich repeat domain. |
| Commentary on involvement of protein in cancer: | 2/111 CNS-, 1/101 kidney-, and 1 pharyngeal tumour sample were also mutated (Sanger COSMIC). |