Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NIT1 |
| Gene Name: | NIT1 |
| Protein Full Name: | Nitrilase homolog 1 |
| Alias: | Nitrilase 1 |
| Mass (Da): | 35896 |
| Number AA: | 327 |
| UniProt ID: | Q86X76 |
| Locus ID: | 481 |
| COSMIC ID: | NIT1 |
| Gene location on chromosome: | 1q21-q22 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.25 |
| Commentary on involvement of protein in cancer: | Play a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. it is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 |