Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DDX42 |
| Gene Name: | DDX42 |
| Protein Full Name: | ATP-dependent RNA helicase DDX42 |
| Alias: | DEAD box protein 42; RHELP; RNA helicase-like protein; RNA helicase-related protein; RNAHP; SF3b125; Splicing factor 3B-associated 125 kDa protein |
| Mass (Da): | 102975 |
| Number AA: | 938 |
| UniProt ID: | Q86XP3 |
| Locus ID: | 1643 |
| COSMIC ID: | DDX42 |
| Gene location on chromosome: | 11p12-p11 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.72 |
| Normal role description: | DDX42 is a member of the Asp-Glu-Ala-Asp (DEAD) box protein family, and functions as a RNA helicase; it also has a pro-growth/anti-apoptotic affect by inhibiting TP53BP2 -- a apoptosis-stimulating protein. Missense mutations inthis gene have been linked to colon, ovarian, and skin cancers. |
| Commentary on involvement of protein in cancer: | ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. |