Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TMPRSS6 |
| Gene Name: | TMPRSS6 |
| Protein Full Name: | Transmembrane protease serine 6 |
| Alias: | Matriptase-2 |
| Mass (Da): | 90000 |
| Number AA: | 811 |
| UniProt ID: | Q8IU80 |
| Locus ID: | 164656 |
| COSMIC ID: | TMPRSS6 |
| Gene location on chromosome: | 22q12.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19784 |
| Percent of cancer specimens with mutations: | 0.85 |
| Normal role description: | TMPRSS6 is a transmembrane serine protease. It is involved in degradation of collagen, fibronectin and fibrinogen. Other roles include matrix remodeling in the liver, dectection of iron deficiency and urokinase-type plasminogen actiavtion. |