Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MYO18B |
| Gene Name: | MYO18B |
| Protein Full Name: | Myosin-XVIIIb |
| Alias: | BK125H2.1; MY18B; myosin 18B; myosin XVIIIb; Myosin-18B |
| Mass (Da): | 285185 |
| Number AA: | 2567 |
| UniProt ID: | Q8IUG5 |
| Locus ID: | 84700 |
| COSMIC ID: | MYO18B |
| Gene location on chromosome: | 22q12.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19670 |
| Percent of cancer specimens with mutations: | 2.77 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with several point mutations, but no complex, insertion or deletion mutants. |
| Normal role description: | MYO18B is has multiple functions depending on its localization. In the nucleus it regulates muscle specific gene transcription. When in the cytoplasm it is involved in intracellular trafficking. Loss of expression due to deletion, mutation or hypermethylation results in anchorage-independent growth. |