Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC9A9 |
| Gene Name: | SLC9A9 |
| Protein Full Name: | Sodium/hydrogen exchanger 9 |
| Alias: | Exchanger 9; FLJ35613; Nbla00118; NHE9; NHE-9; SL9A9; Sodium/hydrogen exchanger 9; Sodium/proton exchanger NHE9; Solute carrier family 9 (sodium/hydrogen exchanger) member 9; Solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 |
| Mass (Da): | 72565 |
| Number AA: | 645 |
| UniProt ID: | Q8IVB4 |
| Locus ID: | 285195 |
| COSMIC ID: | SLC9A9 |
| Gene location on chromosome: | 3q24 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.84 |
| Commentary on involvement of protein in cancer: | May act in electroneutral exchange of protons for Na+ across membranes. Involved in the effusion of Golgi luminal H+ in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintainance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. |