Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NAV2 |
| Gene Name: | NAV2 |
| Protein Full Name: | Neuron navigator 2 |
| Alias: | FLJ10633; FLJ11030; FLJ23707; HELAD1; Helicase APC down-regulated 1; Helicase, APC down-regulated 1; KIAA1419; Neuron navigator 2; POMFIL2; Pore membrane and/or filament interacting like protein 2; Pore membrane and/or filament-interacting-like protein 2; RAINB1; Retinoic acid inducible gene in neuroblastoma 1; Retinoic acid inducible in neuroblastoma 1; Steerin2; Steerin-2; Unc-53 homolog 2; Unc53H2 |
| Mass (Da): | 268133 |
| Number AA: | 2488 |
| UniProt ID: | Q8IVL1 |
| Locus ID: | 89797 |
| COSMIC ID: | NAV2 |
| Gene location on chromosome: | 11p15.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19715 |
| Percent of cancer specimens with mutations: | 2 |
| Normal role description: | NAV2 is a helicase that possesses 3' to 5' activity, as well as exonuclease activity. It is a member of the neuron navigator family, and it plays a role in cell growth and migration. It has been found to be upregulated in colon cancers. Mutation in this gene have also been found in ovarian, pancrease, and skin cancers. |
| Commentary on involvement of protein in cancer: | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. |