Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KSR1 |
| Gene Name: | KSR1 |
| Protein Full Name: | Kinase suppressor of Ras 1 |
| Alias: | CAP kinase; Ceramide-activated protein kinase; HB; HB protein; Kinase KSR1; Kinase suppressor of ras 1; Kinase suppressor of RAS-1; KSR1; RSU2 |
| Mass (Da): | 102032 |
| Number AA: | 921 |
| UniProt ID: | Q8IVT5 |
| Locus ID: | 8844 |
| COSMIC ID: | KSR1 |
| Gene location on chromosome: | 17q11.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19981 |
| Percent of cancer specimens with mutations: | 0.78 |
| Normal role description: | Acts as a scaffold for the Raf/MEK/ERK kinase cascade. No specific mutations have been directly implicated in oncogenesis although loss of KSR1 function will blunt the Ras pathway and therefore attenuate its oncogenic potential. |