Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WWC1 |
| Gene Name: | WWC1 |
| Protein Full Name: | Protein KIBRA |
| Alias: | KIAA0869; KIBRA; WW and C2 domain containing 1 |
| Mass (Da): | 125301 |
| Number AA: | 1113 |
| UniProt ID: | Q8IX03 |
| Locus ID: | 23286 |
| COSMIC ID: | WWC1 |
| Gene location on chromosome: | 5q34 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19691 |
| Percent of cancer specimens with mutations: | 0.98 |
| Normal role description: | WWC1 is regulatory protein found to interact many proteins through WW domains. WWC1 interacts with the protein kinase M zeta (PKM-zeta) isoform of Protein kinase C zeta. This protein may also have a role in organ development through regulating the hippo signalling pathway. WWC1 promotes phosphorylation of hippo pathway effectors LATS1/LATS2. WWC1 has been found to be expressed in breast cancer cell lines. WWC1 may mediate estrogen receptor transactivation in cancer by recruit to histone H3. |
| Commentary on involvement of protein in cancer: | Less than 3% mutations in breast. |