Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TH1L |
| Gene Name: | TH1L |
| Protein Full Name: | Negative elongation factor C/D |
| Alias: | TH1-like protein |
| Mass (Da): | 66247 |
| Number AA: | 590 |
| UniProt ID: | Q8IXH |
| Locus ID: | 51497 |
| COSMIC ID: | TH1L |
| Gene location on chromosome: | 20q13 |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.52 |
| Commentary on involvement of protein in cancer: | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. |