Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RHOT1 |
| Gene Name: | RHOT1 |
| Protein Full Name: | Mitochondrial Rho GTPase 1 |
| Alias: | Rac-GTP-binding protein-like protein;Ras homolog gene family member T1 |
| Mass (Da): | 70784 |
| Number AA: | 618 |
| UniProt ID: | Q8IXI2 |
| Locus ID: | 5528 |
| COSMIC ID: | RHOT1 |
| Gene location on chromosome: | 17q11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.5 |
| Normal role description: | ROHT1 is a mitochondrial GTPase. It is involved in mitochondrial trafficking. ROHT1 is likely regulates anterograde transport of mitochondria and their subcellular distribution. Missense mutations in this gene have been found in ovarian tumors. |